Formestane is a synthetic steroidal substance with antineoplastic activity.Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
Application
Formestane has a very long active life on the order of 24-36 hours.This amount will usually last you about 3-4 weeks at a sufficient dosage of 200-400mg per day.I have found 200mg a day to be perfect for on cycle anti-estrogen usage and for post-cycle recovery of natural testosterone.Formestane has zero negative feedback (even though it is an androgen by definition) and serves to elevate natural testosterone as well as any anti-estrogen/anti-aromatase drug out there, next to clomid.
Formestane attacks the aromatase enzyme and is therefore a first line inhibitor.So if you need immediate relief of estrogen during your cycle, you need a second class drug (estrogen receptor blocker) such as nolvadex or clomid.Formestane is a lot like arimidex in its mechanism of action in attacking the aromatase enzyme itself.
Formestane decreases SHBG by 34% thus increasing androgen activity, which basically makes androgens/steroids in your systems MORE effective WITHOUT any increase in dosage.
Formestane increases IGF-1 levels by a whopping 26%.Doing so creates the perfect anabolic muscle building environment on cycle, off cycle and during pct.
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